Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cocaine withdrawal in Planaria.

R B Raffa1, J M Valdez

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA 19140, USA. rraffa@nimbus.temple.edu

European Journal of Pharmacology
|November 8, 2001
PubMed
Summary

Planarians exposed to cocaine exhibit withdrawal symptoms when moved to drug-free water. This abstinence-induced behavior, measured by a new velocity metric, was worsened by ultraviolet light.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Galcanezumab: a humanized monoclonal antibody for the prevention of migraine and cluster headache.

Drugs of today (Barcelona, Spain : 1998)·2020
Same author

Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs).

Journal of clinical pharmacy and therapeutics·2018
Same author

Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia.

Journal of clinical pharmacy and therapeutics·2018
Same author

The role and mechanism of action of menthol in topical analgesic products.

Journal of clinical pharmacy and therapeutics·2018
Same author

Nature's first "atypical opioids": Kratom and mitragynines.

Journal of clinical pharmacy and therapeutics·2018
Same author

The rapid-onset antidepressant effect of ketamine: More surprises?

Journal of clinical pharmacy and therapeutics·2017

Area of Science:

  • Neuroscience
  • Pharmacology
  • Planarian biology

Background:

  • Drug addiction and withdrawal are complex phenomena.
  • Planarians offer a simple model for studying behavioral responses to drugs.
  • Previous research suggests ultraviolet light can affect drug-receptor interactions in planarians.

Purpose of the Study:

  • To investigate cocaine withdrawal behavior in planarians.
  • To quantify withdrawal using a novel locomotor velocity metric.
  • To determine the effect of ultraviolet light on cocaine withdrawal in planarians.

Main Methods:

  • Planarians were exposed to varying concentrations of cocaine.
  • Locomotor velocity was measured in cocaine-free and cocaine-containing water.
  • The effect of 254 nm ultraviolet light exposure was assessed.

Main Results:

  • Cocaine-exposed planarians showed decreased locomotor velocity in cocaine-free water, indicating withdrawal.
  • This abstinence-induced decrease in velocity was dose-dependent.
  • Ultraviolet light exposure enhanced the withdrawal-induced decrease in locomotor velocity.

Conclusions:

  • Planarians exhibit a measurable cocaine withdrawal response.
  • A novel locomotor velocity metric effectively quantifies this behavior.
  • Ultraviolet light exacerbates cocaine withdrawal symptoms in planarians, suggesting interference with drug-receptor interactions.

Related Experiment Videos