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Updated: Aug 5, 2026

Isolation and Large Scale Expansion of Adult Human Endothelial Colony Forming Progenitor Cells
12:17

Isolation and Large Scale Expansion of Adult Human Endothelial Colony Forming Progenitor Cells

Published on: October 28, 2009

Homeostatic expansion occurs independently of costimulatory signals

M Prlic1, B R Blazar, A Khoruts

  • 1Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.

Journal of Immunology (Baltimore, Md. : 1950)
|November 8, 2001
PubMed

Naive T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognition of specific self peptide/MHC complexes. Since costimulation signals regulate the T cell response to foreign Ags, we asked whether they also regulate homeostatic expansion. We report in this study that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11.10 TCR transgenic T cells, we confirmed that CD28 expression was dispensable for homeostatic expansion, and showed that the presence of endogenous CD4(+)CD25(+) regulatory cells did not detectably influence homeostatic expansion. The implications of these findings with respect to regulation of T cell homeostasis and autoimmunity are discussed.

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Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade11:55

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