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Related Experiment Videos

Increased CCR4 expression in active systemic lupus erythematosus.

K Hase1, K Tani, T Shimizu

  • 1Third Department of Internal Medicine, School of Medicine, Tokushima University, Japan.

Journal of Leukocyte Biology
|November 8, 2001
PubMed
Summary

Chemokine receptor CCR4 is highly expressed on T cells in active lupus (SLE) patients, correlating with disease severity. Its levels decrease with treatment, suggesting CCR4

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Area of Science:

  • Immunology
  • Rheumatology

Background:

  • Chemokine receptor 4 (CCR4) is selectively expressed on Th2-type T cells.
  • CCR4 mediates Th2-dominant immune responses.
  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation.

Purpose of the Study:

  • To analyze CCR4 expression in active SLE patients.
  • To determine the clinical relevance of CCR4 in SLE.
  • To investigate the correlation between CCR4 expression, disease activity, and treatment response.

Main Methods:

  • Flow cytometry (FACS) analysis using anti-human CCR4 monoclonal antibody.
  • Comparison of CCR4 expression in active SLE patients, inactive SLE patients, and healthy controls.
  • Correlation analysis with SLE disease activity index (SLEDAI) scores, serum anti-dsDNA antibody levels, and IL-10 levels.

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Main Results:

  • Higher CCR4 expression was observed on peripheral blood CD4+ T lymphocytes in active SLE patients compared to controls and inactive patients.
  • CCR4 expression significantly correlated with SLEDAI scores.
  • CCR4 expression decreased significantly after corticosteroid therapy, paralleling reductions in anti-dsDNA antibody and SLEDAI scores.
  • Serum IL-10 levels were elevated in active SLE patients and correlated significantly with CCR4 expression.

Conclusions:

  • Th2 immune responses are predominant in active SLE.
  • CCR4 expression is a potential biomarker for SLE disease activity and course.
  • Targeting CCR4 may offer a therapeutic strategy for SLE.