Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myositis-specific autoantibodies: overview and recent developments.

G J Hengstman1, B G van Engelen, W T Vree Egberts

  • 1Neuromuscular Centre Nijmegen, Institute of Neurology, University Medical Centre Nijmegen, Nijmegen, The Netherlands. g.hengstman@czzoneu.azn.nl

Current Opinion in Rheumatology
|November 8, 2001
PubMed
Summary

Myositis-specific autoantibodies (MSAs) are detected in many idiopathic inflammatory myopathy (IIM) patients and link to specific clinical features. Understanding these MSAs aids in diagnosing and managing IIM, improving patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sarco/endoplasmatic reticulum calcium ATPase activity in healthy muscle and Brody disease.

Biochemistry and biophysics reports·2026
Same author

Facing facial weakness: psychosocial outcomes of facial weakness and reduced facial function in facioscapulohumeral muscular dystrophy.

Disability and rehabilitation·2022
Same author

1st FSHD European Trial Network workshop:Working towards trial readiness across Europe.

Neuromuscular disorders : NMD·2021
Same author

Scapular dyskinesis in myotonic dystrophy type 1: clinical characteristics and genetic investigations.

Journal of neurology·2019
Same author

Functional impairments, fatigue and quality of life in RYR1-related myopathies: A questionnaire study.

Neuromuscular disorders : NMD·2018
Same author

Repeatability and reliability of muscle relaxation properties induced by motor cortical stimulation.

Journal of applied physiology (Bethesda, Md. : 1985)·2018

Area of Science:

  • Rheumatology
  • Immunology
  • Neurology

Background:

  • Myositis-specific autoantibodies (MSAs) are biomarkers in idiopathic inflammatory myopathies (IIM).
  • MSAs are present in nearly half of IIM patients, correlating with distinct clinical phenotypes.
  • Established associations, like anti-Jo-1 with anti-synthetase syndrome, are clinically significant, while others require further validation.

Purpose of the Study:

  • To provide a comprehensive review of myositis-specific autoantibodies (MSAs).
  • To elucidate the biochemical basis, clinical utility, and future potential of MSAs in understanding IIM.
  • To clarify established and emerging associations between MSAs and IIM clinical characteristics.

Main Methods:

  • Literature review of clinical and epidemiological studies on MSAs in IIM.

Related Experiment Videos

  • Analysis of biochemical data related to identified MSAs.
  • Synthesis of current knowledge on the clinical significance and diagnostic value of MSAs.

    • Main Results:

    • Identified various MSAs and their prevalence in IIM.
    • Detailed established clinical associations (e.g., anti-Jo-1/anti-synthetase syndrome) and less defined ones (e.g., anti-SRP/cardiac involvement).
    • Highlighted the clinical utility of MSAs in IIM diagnosis and patient stratification.

    Conclusions:

    • MSAs are crucial for understanding IIM heterogeneity.
    • Accurate interpretation of MSA associations can guide clinical management and reduce diagnostic uncertainty.
    • Further research into MSAs promises enhanced diagnostic and therapeutic strategies for IIM.