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Related Experiment Videos

Mild serotonin syndrome on fluvoxamine.

Y Kaneda1, Y Ishimoto, T Ohmori

  • 1Department of Neuropsychiatry, University of Tokushima School of Medicine, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan. kaneday@clin.med.tokushimau.ac.jp

The International Journal of Neuroscience
|November 9, 2001
PubMed
Summary

This study found that while no patients met full serotonin syndrome criteria, 43.2% experienced mild symptoms during fluvoxamine treatment, suggesting milder forms may occur.

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Area of Science:

  • Pharmacology
  • Clinical Psychology
  • Psychiatry

Background:

  • Serotonin syndrome (SS) is a potentially severe condition.
  • Fluvoxamine is a commonly prescribed selective serotonin reuptake inhibitor.
  • Assessing SS symptoms in clinical settings is crucial for patient safety.

Purpose of the Study:

  • To investigate the prevalence and severity of serotonin-related symptoms in patients receiving fluvoxamine.
  • To utilize the Japanese version of the Serotonin Syndrome Scale (JSSS) for symptom assessment.
  • To explore the relationship between fluvoxamine dosage and SS symptom severity.

Main Methods:

  • A preliminary study involving 37 patients (20 with mood disorders, 17 with anxiety disorders) diagnosed with DSM-IV criteria.
  • Informed consent was obtained from all participants.

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  • Serotonin-related symptoms were evaluated using Sternbach's criteria and the JSSS.

    • Main Results:

    • No patients met the diagnostic criteria for SS according to Sternbach's criteria or reached the JSSS cutoff score of 7.
    • 16 out of 37 patients (43.2%) exhibited at least one symptom measured by the JSSS.
    • A positive but non-significant correlation was observed between JSSS scores and fluvoxamine dosage.

    Conclusions:

    • Milder forms of serotonin syndrome may be present in patients undergoing fluvoxamine therapy.
    • The JSSS can identify subclinical serotonin-related symptoms.
    • Further research is warranted to understand the clinical significance of these milder symptoms.