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Related Experiment Videos

Open-field behavior of house mice selectively bred for high voluntary wheel-running.

A M Bronikowski1, P A Carter, J G Swallow

  • 1Department of Zoology, University of Wisconsin, Madison 53706, USA. abronikowski@facstaff.wisc.edu

Behavior Genetics
|November 9, 2001
PubMed
Summary

Genetic selection for high voluntary wheel-running in mice did not alter traditional open-field behaviors like distance traveled or anxiety. However, selected mice showed reduced turning and slower wall approach, suggesting subtle behavioral modifications.

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Area of Science:

  • Animal Behavior
  • Genetics
  • Rodent Models

Background:

  • Open-field tests are standard for assessing rodent locomotor activity and emotionality.
  • Genetic selection studies explore correlations between different behavioral traits.
  • Previous research indicated no link between open-field activity and wheel-running.

Purpose of the Study:

  • To investigate the genetic correlation between high voluntary wheel-running behavior and standard open-field test measures in mice.
  • To determine if selective breeding for wheel-running impacts locomotor activity, anxiety-related behaviors, or exploratory patterns in the open field.
  • To provide a converse test to studies selecting for open-field activity.

Main Methods:

  • House mice (Mus domesticus) from selected lines (high wheel-running) and control lines were used.

Related Experiment Videos

  • Open-field tests were conducted over 3 minutes in a 1-m² arena on two consecutive days.
  • Video recordings were analyzed for distance traveled, defecation, interior time, center distance, turning frequency, and latency to wall.

    • Main Results:

    • Selected lines showed no significant differences in distance traveled, defecation, interior time, or average distance from the arena center compared to controls.
    • Mice from selected lines exhibited significantly less turning during their movement paths.
    • Female mice from selected lines demonstrated slower travel times to reach the arena wall.

    Conclusions:

    • Traditional open-field measures of locomotor activity and anxiety show little genetic correlation with high voluntary wheel-running behavior.
    • Selective breeding for wheel-running may subtly alter exploratory patterns, such as reduced turning and altered thigmotaxis (wall-avoidance).
    • These findings offer a valuable counterpoint to prior research and highlight the nuanced relationship between different behavioral phenotypes.