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High-capacity 'gutless' adenoviral vectors
S Kochanek1, G Schiedner, C Volpers
1Center for Molecular Medicine, University of Cologne, Germany. Stefan.Kochanek@medizin.uni-koeln.de
Current Opinion in Molecular Therapeutics
|November 9, 2001
Abstract:
Adenoviral vectors are promising gene transfer vehicles for different gene therapy applications. High-capacity adenoviral (HC-Ad) vectors address some of the problems that have been observed with replication-defective, E1-deleted first-generation adenoviral vectors: toxicity and immunogenicity due to viral gene expression and 7 to 8 kb capacity limit for the transport of therapeutic DNA. This review summarizes HC-Ad vector-related publications from the past 18 months that are mainly concerned with vector design/production and in vivo applications in different murine models.