Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

One-dimensional DOSY.

N M Loening1, J Keeler, G A Morris

  • 1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, United Kingdom. Niko_Loening@alumni.hmc.edu

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|November 9, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rheo-dissolution: A new platform for the simultaneous measurement of rheology and drug release.

Carbohydrate polymers·2019
Same author

Structure and physicochemical properties of Ghanaian grewia gum.

International journal of biological macromolecules·2018
Same author

Structure-Function Relationships in Pectin Emulsification.

Food biophysics·2018
Same author

Relaxation-encoded NMR experiments for mixture analysis: REST and beer.

Chemical communications (Cambridge, England)·2017
Same author

Structural characterisation and rheological properties of a polysaccharide from sesame leaves (Sesamum radiatum Schumach. & Thonn.).

Carbohydrate polymers·2016
Same author

Increasing the quantitative bandwidth of NMR measurements.

Chemical communications (Cambridge, England)·2016
Same journal

Localization-driven exchange contrast in diffusion exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

4.5 Tesla superconducting miniature magnet in liquid nitrogen.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Folding and unfolding dynamics of a DNA aptamer studied by heteronuclear <sup>1</sup>H-<sup>13</sup>C correlation zz-exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Multi-spin control from one-spin pulses.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Effects of proton exchange on the lifetimes of long-lived states in aliphatic chains.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
See all related articles

A novel nuclear magnetic resonance (NMR) experiment simplifies diffusion measurements by encoding information into peak shapes within a single dimension, offering an alternative to traditional methods.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Physical Chemistry

Background:

  • Diffusion-ordered spectroscopy (DOSY) is crucial for analyzing molecular mixtures.
  • Conventional DOSY experiments require multi-dimensional data acquisition.
  • Simplifying DOSY acquisition can enhance its applicability.

Purpose of the Study:

  • To introduce a new, single-dimensional NMR experiment for correlating diffusion coefficients and chemical shifts.
  • To demonstrate that this experiment provides information comparable to conventional DOSY.
  • To enable efficient diffusion analysis in complex samples.

Main Methods:

  • Development of a new NMR experiment utilizing nonuniform magnetic field gradients.
  • Encoding diffusion information into peak lineshapes within a single spectral dimension.

Related Experiment Videos

  • Fitting of spectral lineshapes to extract diffusion coefficients for individual peaks.

    • Main Results:

    • The new experiment successfully correlates diffusion coefficients and chemical shifts.
    • Diffusion information is encoded into peak lineshapes, enabling single-dimensional analysis.
    • Qualitative DOSY spectra can be generated from a single 1D experiment; quantitative data requires reference experiments.

    Conclusions:

    • The presented NMR experiment offers a simplified approach to obtaining DOSY-like information.
    • This method reduces experimental complexity by using a single dimension and nonuniform gradients.
    • The technique holds potential for more accessible diffusion analysis in various chemical contexts.