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Herbicidins C and E, two new necleoside antibiotics.
The Journal of Antibiotics
|September 1, 1979
Summary
Streptomyces saganonensis produced two new nucleoside antibiotics, herbicidins C and E. These compounds show inhibitory activity against Chinese cabbage germination and blue-green algae.
Area of Science:
- Microbiology
- Natural Products Chemistry
- Biochemistry
Background:
- Streptomyces saganonensis is known for producing antibiotics herbicidins A and B.
- The strain has potential for producing other bioactive compounds.
Purpose of the Study:
- To isolate and characterize new antibiotics produced by Streptomyces saganonensis No. 4075.
- To evaluate the biological activity of the newly discovered compounds.
Main Methods:
- Submerged culture of Streptomyces saganonensis No. 4075.
- Antibiotic isolation using resinous adsorbent, methanol elution, and silica-gel chromatography.
- Physicochemical characterization of isolated compounds.
Main Results:
- Two new nucleoside antibiotics, herbicidins C and E, were isolated.
- Herbicidins C and E possess an adenine moiety in their molecular structures.
- Herbicidins C and E exhibited inhibitory effects on Chinese cabbage germination and Anacystis nidulans growth.
Conclusions:
- Streptomyces saganonensis No. 4075 produces novel nucleoside antibiotics, herbicidins C and E.
- Herbicidins C and E demonstrate potential as herbicides or algicides.