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Adult moyamoya disease with peripheral artery involvement
Abstract:
We report the case of a young white woman in whom cerebrovascular moyamoya disease, which was associated with nonarteriosclerotic peripheral artery disease of the subclavian, iliac, and femoropopliteal arteries, was diagnosed by means of angiography. During 8 years of follow-up, the peripheral artery disease progressed, without any signs characteristic of systemic inflammation or vasculitis, leading to severe calf and arm claudication. Despite the absence of histologic confirmation, this observation strongly suggests that peripheral artery involvement may be a feature of moyamoya disease. To our knowledge, this is the first report of an association of classical cerebrovascular moyamoya disease with peripheral artery disease.
Insights
Moyamoya disease, a cerebrovascular condition, was found to be associated with peripheral artery disease in a young woman. This case suggests peripheral artery issues may be a feature of moyamoya disease.
Area of Science:
- Vascular Neurology
- Cardiovascular Medicine
Background:
- Moyamoya disease is a rare, progressive cerebrovascular disorder characterized by stenosis of the terminal portion of the internal carotid arteries.
- Peripheral artery disease (PAD) involves the narrowing or blockage of arteries outside the brain, typically in the legs.
Observation:
- A case study of a young woman diagnosed with cerebrovascular moyamoya disease via angiography.
- The patient also presented with nonarteriosclerotic peripheral artery disease affecting the subclavian, iliac, and femoropopliteal arteries.
- Over an 8-year follow-up, her peripheral artery disease progressed, causing severe calf and arm claudication without systemic inflammation or vasculitis indicators.
Findings:
- This observation suggests a potential association between moyamoya disease and peripheral artery disease.
- The progression of PAD in this patient, despite the absence of typical inflammatory markers, highlights a possible link.
- This is the first reported case linking classical moyamoya disease with peripheral artery disease.
Implications:
- Further research is warranted to investigate the potential link between moyamoya disease and peripheral artery disease.
- This finding may necessitate broader vascular screening in patients diagnosed with moyamoya disease.
- Understanding this association could lead to improved diagnostic and therapeutic strategies for affected individuals.