Evidence-based medicine and everyday reality
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Updated: Oct 3, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
1School of Medical Education, Faculty of Medicine, University of New South Wales, Sydney. ken.cox@unsw.edu.au
Abstract:
Everyday-life judgements are "fast and frugal" and not numerically rigorous. Clinicians do not (yet) incorporate numerical evidence into their "thinking on the run". Evidence-based medicine is important in generating accurate data, but the existence of data doesn't ensure their use. Only "real time" observation of clinical events and the thinking that shaped them can provide plausible data on how external evidence and internal experience do, or don't, meld within clinical care.
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