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Related Experiment Videos

Testosterone dose-response relationships in healthy young men.

S Bhasin1, L Woodhouse, R Casaburi

  • 1Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA. SBHASIN@UCLA.EDU

American Journal of Physiology. Endocrinology and Metabolism
|November 10, 2001
PubMed
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Testosterone dose impacts muscle mass, strength, and body composition in men. Different bodily processes respond uniquely to testosterone levels, with sexual function and cognition unaffected by dose.

Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Androgen Research

Background:

  • Testosterone is known to influence muscle mass and strength.
  • The dose-dependent effects and varying requirements for different androgen-dependent processes remain unclear.

Purpose of the Study:

  • To investigate the dose-dependent effects of testosterone enanthate on body composition, muscle characteristics, strength, power, sexual and cognitive functions, and various biomarkers.
  • To determine if different androgen-dependent processes exhibit similar dose-response relationships.

Main Methods:

  • 61 eugonadal men (18-35 years) received GnRH agonist to suppress endogenous testosterone.
  • Participants were randomized to weekly injections of 25, 50, 125, 300, or 600 mg testosterone enanthate for 20 weeks.

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  • Standardized energy and protein intake were maintained.

    • Main Results:

    • Increased fat-free mass, muscle size, strength, and power were dose-dependently correlated with testosterone concentrations.
    • Changes in hemoglobin and insulin-like growth factor I (IGF-I) were positively correlated with testosterone.
    • Fat mass and high-density lipoprotein (HDL) cholesterol decreased with increasing testosterone dose.
    • Sexual function, cognitive function, and prostate-specific antigen (PSA) levels showed no significant changes across doses.

    Conclusions:

    • Circulating testosterone concentrations are associated with dose- and concentration-dependent changes in body composition, muscle parameters, and metabolic markers.
    • A single linear dose-response relationship generally applies, but specific androgen-dependent processes show distinct sensitivities.
    • Testosterone dose significantly influences physical and metabolic outcomes, but not sexual function, cognition, or PSA levels in this cohort.