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Related Experiment Videos

Imaging transgenic animals.

T F Budinger1, D A Benaron, A P Koretsky

  • 1Department of Bioengineering and Center for Functional Imaging, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.

Annual Review of Biomedical Engineering
|November 10, 2001
PubMed
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Researchers review non-invasive imaging techniques for small transgenic and eugenic animals. Technologies like radionuclide emission, magnetic resonance imaging (MRI), and optical methods offer high resolution and sensitivity for studying these models.

Area of Science:

  • Biomedical Imaging
  • Preclinical Research
  • Animal Models

Background:

  • Small transgenic and eugenic animals (as small as 30 g) are crucial for biomedical research.
  • Non-invasive study methods are needed to monitor these animals without causing distress or altering biological processes.
  • Advancements in imaging technologies provide unprecedented opportunities for in-vivo analysis.

Purpose of the Study:

  • To review current non-invasive imaging technologies applicable to small animal studies.
  • To highlight the capabilities and resolutions of various imaging modalities.
  • To provide examples of how these technologies are applied in research.

Main Methods:

  • Radionuclide emission imaging (e.g., PET, SPECT) with 1-2 mm resolution.

Related Experiment Videos

  • Magnetic Resonance Imaging (MRI) with 100-micron resolution.
  • Optical imaging techniques including fluorescence and bioluminescence with high sensitivity.

    • Main Results:

    • These technologies enable detailed, non-invasive visualization and analysis of small animal physiology and pathology.
    • High resolution and sensitivity allow for the study of processes at the cellular and molecular level.
    • The reviewed methods are currently being applied to diverse small-animal research areas.

    Conclusions:

    • A range of advanced imaging technologies are available for non-invasive small animal research.
    • These methods, including radionuclide, MRI, and optical techniques, offer complementary strengths for preclinical studies.
    • The application of these technologies significantly enhances the ability to study disease models and therapeutic interventions in vivo.