Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibody engineering.

J Maynard1, G Georgiou

  • 1Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.

Annual Review of Biomedical Engineering
|November 10, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increasing COVID-19 vaccination in the United States: projected impact on cases, hospitalizations, and deaths by age and racial group.

Public health·2022
Same author

Prediction of complicated appendicitis risk in children.

European review for medical and pharmacological sciences·2021
Same author

Effect of root canal irrigant (sodium hypochlorite & saline) delivery at different temperatures and durations on pre-load and cyclic-loading surface-strain of anatomically different premolars.

Journal of the mechanical behavior of biomedical materials·2021
Same author

The Avatar Acceptability Study: Survivor, Parent and Community Willingness to Use Patient-Derived Xenografts to Personalize Cancer Care.

EBioMedicine·2018
Same author

Measurement of the relative prompt production rate of <i>χ</i><sub>c2</sub> and <i>χ</i><sub>c1</sub> in pp collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same author

Jet and underlying event properties as a function of charged-particle multiplicity in proton-proton collisions at [Formula: see text].

The European physical journal. C, Particles and fields·2015
Same journal

Physics-Informed Machine Learning in Biomedical Science and Engineering.

Annual review of biomedical engineering·2026
Same journal

Advancements and Challenges in Computer-Assisted Medical Interventions for Image-Guided Prostate Cancer Treatments.

Annual review of biomedical engineering·2026
Same journal

Recent Advances in mRNA Therapeutic Cancer Vaccines.

Annual review of biomedical engineering·2026
Same journal

Artificial Intelligence-Based Analysis of Laparoscopic Imaging for Intraoperative Surgical Decision Support.

Annual review of biomedical engineering·2026
Same journal

Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.

Annual review of biomedical engineering·2026
Same journal

Digital Twins for Biofluids.

Annual review of biomedical engineering·2026
See all related articles

This review covers novel methods for generating human antibodies and enhancing their antigen affinity. It also discusses antibody fragment production and recombinant antibody applications in biotechnology.

Area of Science:

  • Biotechnology
  • Immunology
  • Molecular Biology

Background:

  • Antibodies possess high affinity and specificity, making them crucial for biotechnology and biomedical applications.
  • Antibody engineering has advanced significantly due to in vitro isolation technologies and bacterial expression systems.

Purpose of the Study:

  • To review methods for de novo generation of human antibodies.
  • To discuss engineering antibodies for increased antigen affinity.
  • To present antibody fragment production and recombinant antibody applications.

Main Methods:

  • In vitro isolation of antibodies from combinatorial libraries.
  • Functional expression of antibodies in bacteria.
  • Engineering techniques for enhanced antibody affinity.

Related Experiment Videos

Main Results:

  • Overview of de novo human antibody generation methods.
  • Strategies for improving antibody-antigen affinity.
  • Methods for producing functional antibody fragments.

Conclusions:

  • Novel technologies have revolutionized antibody generation and engineering.
  • Recombinant antibodies offer diverse applications in biotechnology and medicine.