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Related Experiment Videos

Imaging three-dimensional cardiac function.

W G O'Dell1, A D McCulloch

  • 1Department of Bioengineering, University of California San Diego, La Jolla, California 92093-0412, USA. wodell@ucsd.edu

Annual Review of Biomedical Engineering
|November 10, 2001
PubMed
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This study explores 3-D cardiac mechanics, detailing imaging techniques like MRI for quantifying myocardial deformation and function. Advanced methods assess fiber architecture, aiding in understanding cardiac stress and work distribution for clinical applications.

Area of Science:

  • Cardiovascular imaging and mechanics
  • Biomedical engineering
  • Cardiac physiology

Background:

  • Three-dimensional (3-D) myocardial deformation is influenced by ventricular geometry, muscle fiber architecture, and material properties.
  • Accurate assessment of cardiac mechanical function is crucial for understanding heart disease.

Purpose of the Study:

  • To review imaging modalities for visualizing and quantifying 3-D cardiac mechanical function.
  • To demonstrate methods for quantifying ventricular anatomy, cavity volumes, and myocardial wall motion.
  • To explore advanced techniques for assessing myocardial fiber architecture and its clinical applications.

Main Methods:

  • Review of imaging modalities including X-ray angiography, echocardiography, computed tomography, and magnetic resonance (MR) imaging (MRI).

Related Experiment Videos

  • Quantification of ventricular anatomy, cavity volumes, and 3-D surface reconstructions.
  • Analysis of myocardial wall motion using MRI and tissue Doppler imaging.
  • Calculation of 3-D regional strains from motion maps and MRI tagging.
  • Presentation of a technique for assessing myocardial-fiber architecture.

    • Main Results:

    • Demonstration of 3-D surface reconstructions for anatomical and volumetric quantification.
    • Illustration of 3-D regional strain calculations using clinical MRI tagging.
    • Presentation of a novel technique for assessing myocardial-fiber architecture.

    Conclusions:

    • Quantification of 3-D cardiac function, including anatomy, regional strains, and fiber architecture, has significant potential for fundamental science and clinical applications.
    • These methods can aid in determining myocardial stress and work distributions.
    • Advanced imaging and analysis techniques offer new insights into cardiac mechanics.