Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extracorporeal tissue engineered liver-assist devices.

E S Tzanakakis1, D J Hess, T D Sielaff

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Annual Review of Biomedical Engineering
|November 10, 2001
PubMed
Summary

Bioartificial liver (BAL) support shows promise for acute liver failure treatment, offering a bridge to transplantation. Further research is needed to define optimal device properties and risks of xenogeneic treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The application status, challenges and prospects of artificial intelligence in communicable diseases prevention and control of health facilities in China].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]·2025
Same author

[Epidemic characteristics and dynamic changes of spatio-temporal distribution of hemorrhagic fever with renal syndrome in Guangzhou, 2010-2019].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2020
Same author

Maximizing the security of chaotic optical communications.

Optics express·2016
Same author

Comparing maternal and perinatal outcomes in pregnancies complicated by preeclampsia superimposed chronic hypertension and preeclampsia alone.

Clinical and experimental obstetrics & gynecology·2016
Same author

Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK.

Biotechnology and bioengineering·2015
Same author

Metabolic pathways recruited in the production of a recombinant enveloped virus: mining targets for process and cell engineering.

Metabolic engineering·2013

Area of Science:

  • Biomedical Engineering
  • Hepatology
  • Regenerative Medicine

Background:

  • Acute liver failure (ALF) treatment lacks definitive solutions, with artificial systems proving ineffective.
  • Current therapeutic strategies focus on bioartificial liver (BAL) support as a temporary measure.
  • Understanding ALF pathophysiology is crucial for developing effective BAL devices.

Purpose of the Study:

  • To review considerations for developing advanced bioartificial liver (BAL) devices.
  • To explore the potential of BAL systems in supporting ALF patients.
  • To discuss the future trajectory of BAL technology.

Main Methods:

  • Review of current literature on bioartificial liver (BAL) device development.
  • Analysis of key design considerations: cellular and membrane components, system configuration.

Related Experiment Videos

  • Evaluation of mass transfer efficiency in BAL systems.
  • Review of promising hollow-fiber bioreactor-based BAL devices.

    • Main Results:

    • Bioartificial liver (BAL) devices, particularly those using hollow-fiber bioreactors, show significant promise.
    • BAL treatment serves as a critical bridge to liver transplantation for ALF patients.
    • The field of BAL technology is young, with ongoing research into optimal device properties and xenogeneic treatment risks.

    Conclusions:

    • Bioartificial liver (BAL) support represents a hopeful advancement in ALF management.
    • Continued research and development are essential for refining BAL technology and addressing safety concerns.
    • Past and current experiences with BAL systems provide a foundation for future innovations.