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Updated: Aug 15, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
POLYKETIDE PRODUCTION BY PLANT-ASSOCIATED PSEUDOMONADS
CL Bender1, V Rangaswamy, J Loper
1Department of Entomology and Plant Pathology, 110 Noble Research Center, Oklahoma State University, Stillwater, Oklahoma 74078-3032; e-mail: cbender@okstate.edu; vidhya@osuunx.ucc.okstate.edu
Abstract:
Polyketides constitute a huge family of structurally diverse natural products including antibiotics, chemotherapeutic compounds, and antiparasitics. Most of the research on polyketide synthesis in bacteria has focused on compounds synthesized by Streptomyces or other actinomycetes; however, plant-associated pseudomonads also produce a variety of compounds via the polyketide pathway including the phytotoxin coronatine, the antibiotic mupirocin, and the antifungal compounds pyoluteorin and 2,4-diacetylphloroglucinol. This review focuses on the mode of action, regulation, biosynthesis, and genetics of these four compounds and the potential use of Pseudomonas-derived polyketide synthases in the generation of novel compounds with unique activities.
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