Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stereolithographic models simulating trabecular bone and their characterization by thin-slice- and micro-CT.

K Engelke1, C Süss, W A Kalender

  • 1Institute of Medical Physics, University of Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany. klaus.engelke@imp.uni-erlangen.de

European Radiology
|November 10, 2001
PubMed
Summary

Researchers developed enlarged 3D bone phantoms for imaging analysis. These phantoms aid in assessing fracture risk by enabling better characterization of bone structure beyond bone mineral density alone.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MRI underestimates presence and size of knee osteophytes using CT as a reference standard.

Osteoarthritis and cartilage·2023
Same author

The clinical application of high-resolution peripheral computed tomography (HR-pQCT) in adults: state of the art and future directions.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Heterogenous bone response to biologic DMARD therapies in rheumatoid arthritis patients and their relationship to functional indices.

Scandinavian journal of rheumatology·2021
Same author

A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes.

Bone reports·2020
Same author

Guidelines for the assessment of bone density and microarchitecture in vivo using high-resolution peripheral quantitative computed tomography.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Treatment of bone loss in proximal femurs of postmenopausal osteoporotic women with AGN1 local osteo-enhancement procedure (LOEP) increases hip bone mineral density and hip strength: a long-term prospective cohort study.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019

Area of Science:

  • Biomedical Engineering
  • Radiology
  • Materials Science

Background:

  • Assessing osteoporosis fracture risk requires more than bone mineral density; bone structure analysis is crucial.
  • Current methods for in vivo bone structure analysis need validation tools.
  • Realistic phantoms are needed to test imaging techniques and analysis algorithms for bone structure.

Purpose of the Study:

  • To create realistic, enlarged 3D phantoms of trabecular bone for imaging analysis.
  • To evaluate the fidelity of these phantoms in replicating real bone structure.
  • To demonstrate the utility of these phantoms in testing in vivo imaging protocols for bone analysis.

Main Methods:

  • Trabecular bone specimens were used to create enlarged 3D phantoms via stereolithography.

Related Experiment Videos

  • The trabecular network within the phantoms was modeled using hydroxyapatite.
  • Histomorphometric analysis of microCT scans was performed to assess structural replication accuracy.

    • Main Results:

    • Enlarged phantoms (2.5x) demonstrated excellent replication of bone structure.
    • Effective hydroxyapatite concentrations up to 400 mg/cm³ were achieved.
    • Phantom testing revealed limitations for high-resolution CT scanners (>20 lp/cm) due to enlargement.

    Conclusions:

    • The developed 3D bone phantoms are valuable tools for characterizing in vivo imaging procedures.
    • These phantoms facilitate the verification of textural and structural analysis methods for osteoporosis.
    • Further research is needed to optimize phantom properties for various CT scanner resolutions and protocols.