[Ischemic heart disease in patients with syndrome Z]

Syndrome Z was introduced in medical practice by Wilcox in 1996. It includes several cardiovascular risk factors, which are known as syndrome X. Wilcox attached to this cluster of cardiovascular risk factor syndrome sleep apnoe hypopnoe (syndrome SAH). We wanted to know how many patients with syndrome Z have ischaemic heart disease (IHD) and if daytime hypoxaemia deteriorated the prognosis of patients with IHD. We found 15 patients with syndrome Z. The diagnosis of syndrome SAH was verified by device MESAM4. In all patients we provided analysis of blood glucose, cholesterol, triglycerid. We measured blood pressure, circumference of neck and calculated body mass index (BMI). In all patients blood gas was analysed (except one subject, who wasn't finally included in study). The presence of IHD was ascertained in personal history of patients. The patients were divided according to values of oxygen into 2 groups: A--with daytime hypoxaemia (PaO2 < 10 kPa) and B--without daytime hypoxaemia (PaO2 > 10 kPa). There were seven patients in both groups. All patients were men (except one woman in group A). We found one patient with IHD in group A and two in group B. In both groups died one patient, but only in group A with relation to IHD. This finding in this small group support hypothesis that patients with syndrome SAH and several cardiovascular risk factor, who are large time during night hypoxaemic and also during day are threaded by sudden death.