Related Experiment Videos
Tracing the pathway of spindle assembly checkpoint signaling
1Massachusetts Institute of Technology, Dept of Biology, Cambridge 02139, USA.
Developmental Cell
|November 13, 2001
Abstract:
Most current models of spindle assembly checkpoint signaling involve inhibition of the Cdc20-APC by Mad2 protein. Interestingly, a paper from Hongtao Yu and colleagues in this issue of Developmental Cell suggests that the Cdc20/APC can also be inhibited in a Mad2-independent manner by a complex of proteins that includes BubR1.