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The diagnostic quandary of hereditary haemorrhagic telangiectasia vs. CREST syndrome

J B Lee1, D Ben-Aviv, S P Covello

  • 1Ameripath Laboratory, 10th Floor, 145 East 32nd Street, New York, NY 10016, USA. jboklee@netscape.net

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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