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Related Experiment Videos

Gemcitabine-associated CD8+ CD30+ pseudolymphoma.

G Marucci1, E Sgarbanti, A Maestri

  • 1Section of Anatomic Pathology, Department of Oncology, University of Bologna, Bellaria Hospital, via Altura 3, 40139 Bologna, Italy.

The British Journal of Dermatology
|November 13, 2001
PubMed
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Gemcitabine chemotherapy can cause rare, lymphoma-like skin lesions in non-small cell lung cancer patients. Stopping gemcitabine led to complete regression, highlighting the need for pathologist awareness to prevent misdiagnosis.

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Non-small cell lung cancer (NSCLC) is a leading cause of cancer death.
  • Gemcitabine is a common chemotherapeutic agent used in NSCLC treatment.
  • Cutaneous adverse events are known side effects of chemotherapy.

Observation:

  • A 69-year-old man with stage III B NSCLC developed bilateral erythematous abdominal-inguinal lesions after gemcitabine therapy.
  • Histopathology revealed a dense lymphocytic infiltrate with CD30+ cells, mimicking cutaneous lymphoma.
  • Lesions completely regressed upon discontinuation of gemcitabine.

Findings:

  • Gemcitabine-induced skin toxicity can present as lesions resembling malignant lymphoma.
  • The characteristic lymphocytic infiltrate with CD30+ cells is a key diagnostic feature.

Related Experiment Videos

  • Cessation of gemcitabine is an effective treatment for these lesions.

    • Implications:

    • Pathologists must consider gemcitabine-induced skin reactions to avoid misdiagnosing cutaneous lymphoma.
    • Awareness of this rare side effect is crucial for oncologists managing NSCLC patients.
    • Early recognition and management can prevent unnecessary treatments and improve patient outcomes.