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Treating premenstrual dysphoric disorder using serotonin agents.

J Lin1, D S Thompson

  • 1Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA.

Journal of Women'S Health & Gender-Based Medicine
|November 13, 2001
PubMed
Summary

Premenstrual dysphoric disorder (PMDD) affects millions of women. Serotonin agents show promise for treating PMDD, offering relief for a severe form of premenstrual syndrome (PMS).

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Area of Science:

  • Gynecology
  • Psychiatry
  • Pharmacology

Background:

  • Premenstrual syndrome (PMS) impacts 20%-50% of women, with premenstrual dysphoric disorder (PMDD) affecting 3%-9%.
  • Prevalence highlights the need for effective treatments for these common conditions.
  • Distinguishing PMDD from other depressive disorders is challenging due to high comorbidity.

Purpose of the Study:

  • To review the efficacy of treatments for premenstrual disorders, particularly PMDD.
  • To identify effective therapeutic agents for women experiencing severe premenstrual symptoms.

Main Methods:

  • Literature review of studies investigating treatments for PMDD and PMS.
  • Analysis of investigations focusing on serotonin agents and their effectiveness.
  • Consideration of challenges in research, including comorbid depressive disorders.

Main Results:

  • Most studies indicate that serotonin agents are effective in treating PMDD.
  • Challenges in research methodology, such as excluding patients with concurrent depression, were noted.

Conclusions:

  • Serotonin agents are a supported treatment option for premenstrual dysphoric disorder (PMDD).
  • Further research may be needed to refine treatment strategies and address diagnostic complexities.

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