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Published on: May 12, 2019
Physiological range of human chorionic gonadotropin for support of early human pregnancy
C A Richard1, C J Kubik, J A DeLoia
1Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Women's Research Institute, 204 Craft Avenue, Pittsburgh, Pennsylvania 15213, USA. rsicar@mail.magee.edu
Objective:
To determine the physiological range of hCG in early pregnancy.
Design:
Retrospective study of patient charts.
Setting:
Magee-Women's Hospital IVF clinic, Monroeville, Pennsylvania.
Patient(S):
Sixty patients with successful, singleton birth outcomes.
Intervention(S):
Serum hCG measurements on days 12-16 post-oocyte retrieval (OR).
Main Outcome Measure(S):
Lowest values, highest values, mean values, quartile mean values, and 48-hour doubling times for days 12-16 post-OR.
Result(S):
The average production of hCG in successful pregnancies is roughly 4-fold greater than the lowest amount observed in successful pregnancies, suggesting that a considerable excess of hCG is normally produced. Additionally, the average doubling time is almost 2-fold greater than the slowest doubling rate.
Conclusion(S):
The data from this study provide a set of values for the minimum and maximum threshold of hCG for days 12-16 post-OR that may be physiologically required, although not entirely predictive, for a successful IVF pregnancy outcome.
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