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Preventing recurrent second trimester group B streptococcus chorioamnionitis by intermittent prophylactic ampicillin.

D N Marinoff1, A Chinn

  • 1Department of Obstetrics and Gynecology, Alta Bates Medical Center, Berkeley, California, USA.

Obstetrics and Gynecology
|November 13, 2001
PubMed
Summary

Recurrent group B streptococcus chorioamnionitis can cause pregnancy loss. Monthly ampicillin prophylaxis throughout pregnancy may improve outcomes for women with this rare condition.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Infectious Diseases in Pregnancy

Background:

  • Group B Streptococcus (GBS) colonization is common in pregnancy.
  • Second-trimester GBS chorioamnionitis with intact membranes is a rare complication.
  • Recurrence of GBS chorioamnionitis presents significant challenges in subsequent pregnancies.

Observation:

  • A 38-year-old multipara experienced recurrent pregnancy losses due to GBS chorioamnionitis.
  • The patient received monthly prophylactic ampicillin starting at 14 weeks gestation.
  • This intervention led to the delivery of a healthy infant at term.

Findings:

  • Prophylactic ampicillin therapy demonstrated efficacy in preventing GBS chorioamnionitis recurrence.
  • Intermittent antibiotic prophylaxis may be a viable strategy for managing this rare obstetric complication.

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  • Successful term delivery was achieved in a case of recurrent GBS chorioamnionitis.

    • Implications:

    • This case suggests a potential treatment approach for women with recurrent pregnancy loss from GBS chorioamnionitis.
    • Prophylactic antibiotic regimens could improve pregnancy success rates in specific high-risk obstetric cases.
    • Further research may explore optimal antibiotic choices and durations for GBS chorioamnionitis prevention.