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Initial experience with octreotide in the pediatric population.

J C Lam1, S Aters, J D Tobias

  • 1Department of Child Health, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, One Hospital Drive, Columbia, MO 65212, USA.

American Journal of Therapeutics
|November 13, 2001
PubMed
Summary

Octreotide, a somatostatin analogue, shows therapeutic potential in pediatric patients for conditions like gastrointestinal bleeding and pancreatitis. This study evaluates its use in 10 children, highlighting its impact and dosing.

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Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Pharmacology

Background:

  • Octreotide is a somatostatin analogue with established efficacy in adults for various conditions.
  • Limited data exists on octreotide's use and safety in pediatric populations.
  • Pediatric conditions like hyperinsulinism, gastrointestinal bleeding, and pancreatitis may benefit from octreotide therapy.

Purpose of the Study:

  • To retrospectively review the use of octreotide in pediatric patients.
  • To evaluate the therapeutic impact and clinical course of octreotide in infants and children.
  • To discuss dosing regimens and potential applications of octreotide in pediatric diseases.

Main Methods:

  • Retrospective review of 10 pediatric patients (14 days to 17 years) treated with octreotide.

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  • Octreotide administered via continuous intravenous infusion or intermittent bolus dosing.
  • Analysis of clinical outcomes for conditions including gastrointestinal bleeding, pancreatitis, chylous leaks, and hypoglycemia.

    • Main Results:

    • Octreotide was used to treat gastrointestinal bleeding (4 patients), pancreatitis (3 patients), chylous leaks (2 patients), and hypoglycemia (1 patient).
    • The study evaluated the clinical course and therapeutic impact of octreotide in these pediatric cases.
    • Dosing strategies and potential future applications were also discussed.

    Conclusions:

    • Octreotide demonstrates potential therapeutic value in managing diverse conditions in pediatric patients.
    • Further research is warranted to establish optimal dosing and expand indications for octreotide in children.
    • This review contributes to understanding octreotide's role in pediatric medicine.