Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clobetasol propionate foam, 0.05%.

E B Melian1, C M Spencer, B Jarvis

  • 1Adis International Inc, Langhorne, Pennsylvania, USA. demail@adis.com

American Journal of Clinical Dermatology
|November 14, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modafinil : A Review of its Pharmacology and Clinical Efficacy in the Management of Narcolepsy.

CNS drugs·2016
Same author

Quetiapine : A Review of its Use in Schizophrenia.

CNS drugs·2016
Same author

Reconsideration of the derivation of Most Probable Numbers, their standard deviations, confidence bounds and rarity values.

Journal of applied microbiology·2015
Same author

The Yin and Yang of inflammation.

Current molecular medicine·2014
Same author

Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells.

Mucosal immunology·2014
Same author

Application of Illumina next-generation sequencing to characterize the bacterial community of the Upper Mississippi River.

Journal of applied microbiology·2013

Clobetasol propionate foam offers an effective topical treatment for scalp psoriasis, significantly improving symptoms compared to placebo and solution formulations. This superpotent corticosteroid foam demonstrates good efficacy with a favorable safety profile for managing moderate to severe cases.

Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Clobetasol propionate is a superpotent corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties.
  • Foam formulations may enhance topical drug absorption compared to solutions.

Purpose of the Study:

  • To evaluate the efficacy and safety of clobetasol propionate foam for treating moderate to severe scalp psoriasis.
  • To compare the efficacy of clobetasol foam with clobetasol solution and placebo.

Main Methods:

  • A clinical study involving patients with moderate to severe scalp psoriasis.
  • Topical application of clobetasol 0.05% foam twice daily for two weeks.
  • Comparison with placebo foam and clobetasol 0.05% solution.

Main Results:

Related Experiment Videos

  • Clobetasol foam significantly improved all signs and symptoms of scalp psoriasis compared to placebo.
  • Clobetasol foam showed greater improvement in scaling than clobetasol solution after two weeks.
  • 74% of patients treated with clobetasol foam achieved clear or almost clear scalp psoriasis.
  • Adverse events were generally mild and localized to the application site.

Conclusions:

  • Clobetasol propionate foam is an effective and well-tolerated treatment for moderate to severe scalp psoriasis.
  • The foam formulation offers advantages over solution and placebo in improving psoriasis symptoms, particularly scaling.
  • Potential for reversible hypothalamic-pituitary-adrenal axis suppression should be considered with prolonged use.