Aggregation of insulin by chlorpromazine

Chlorpromazine (CPZ) is known to induce hyperglycaemia and can inhibit insulin secretion in both normal subjects and patients with latent diabetes mellitus. In this study, we have tried to determine a probable mechanism by which CPZ causes hyperglycaemia. It is possible that CPZ causes insulin aggregation by the reduction of disulphide bonds, thereby inactivating insulin and hence causing hyperglycaemia.