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Updated: Jul 31, 2026

Tissue Preparation and Immunostaining of Mouse Sensory Nerve Fibers Innervating Skin and Limb Bones
Published on: January 26, 2012
Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy
A G Smith1, P Ramachandran, S Tripp
1Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA. gordon.smith@hsc.utah.edu
Abstract:
The authors describe skin biopsy findings in patients with peripheral neuropathy associated with diabetes and impaired glucose tolerance (IGT). Six patients with IGT, eight with early diabetes-associated neuropathy, and five controls were recruited. Most subjects underwent nerve conduction studies (NCS) and quantitative sensory tests (QST). Skin biopsy was abnormal in all neuropathy subjects and correlated poorly with NCS. Neuropathy associated with IGT primarily affects small fibers and is similar to early diabetes-associated neuropathy.
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