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A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: the effect on stacking of an ethyl group in comparison
K Avasthi1, S Aswal, P R Maulik
1Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Acta Crystallographica. Section C, Crystal Structure Communications
|November 14, 2001
Abstract:
In the crystal structure of 1,1'-(1,3-propanediyl)bis(5-ethyl-6-methylthio-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one), C(19)H(24)N(8)O(2)S(2), the pairs of pyrazolo[3,4-d]pyrimidine rings of the molecule stack between the heterocyclic rings, due to intramolecular pi-pi interactions. The substituted ethyl and methyl groups are comparable as far as intramolecular stacking is concerned.