Related Experiment Videos
Updated statistical data for malignant melanoma in Japan
K Ishihara1, T Saida, A Yamamoto
1Institute for the Analysis of Prognostic Factors in Skin Cancer, 3-14-9 Tsukishima, Chuo-ku, Tokyo 104-0052, Japan.
International Journal of Clinical Oncology
|November 15, 2001
Summary
Japanese melanoma incidence increased from 1987-1996. Early detection of this skin cancer is crucial for improving patient prognosis, as advanced stages show poor survival rates and resistance to chemotherapy.
Area of Science:
- Dermatology
- Oncology
- Epidemiology
Background:
- A statistical investigation of Japanese melanoma patients was conducted between 1987 and 1996.
- Data from 24 medical institutions were analyzed, comparing two chronological groups (1987-1991 and 1992-1996).
Purpose of the Study:
- To assess and compare survival data of Japanese melanoma patients.
- To analyze prognostic factors and treatment efficacy.
Main Methods:
- Analysis of patient data including demographics, lesion characteristics, and treatment.
- Survival rates were assessed using the Kaplan-Meier method and log-rank test.
- A nationwide survey of skin malignancies was also analyzed.
Main Results:
- Malignant melanoma cases steadily increased in Japan from 1987-1996.
- Female patients exhibited higher survival rates than males (10-year survival: 71.6% vs. 55.9% in group B).
- Acral lentiginous melanoma was the most common subtype, and nodular melanoma had the worst prognosis. Advanced stages (IIIB, IV) showed poor outcomes. Tumor thickness and Clark's level were significant prognostic factors.
Conclusions:
- Advanced melanoma has a poor prognosis and is resistant to chemotherapy.
- Early detection of melanoma is essential for improving patient outcomes.
- Distinctive pigmented skin lesions facilitate early diagnosis.