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Dopamine receptor functions: lessons from knockout mice [corrected].

S B Glickstein1, C Schmauss

  • 1Department of Psychiatry/Neuroscience, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA.

Pharmacology & Therapeutics
|November 15, 2001
PubMed
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Gene targeting created mice lacking dopamine (DA) signaling molecules. These knockout mice reveal the roles of DA receptors in locomotion and responses to psychostimulants, aiding research into brain function.

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Dopaminergic (DAergic) transmission is crucial for various brain functions.
  • Gene targeting in mice has enabled the study of specific molecules in DAergic pathways.
  • Previous research has generated mice deficient in dopamine, its transporter, and DA receptors.

Purpose of the Study:

  • To review studies utilizing DA receptor knockout mice and related signaling-deficient models.
  • To compare locomotor phenotypes and psychostimulant responses in these mutant mice.
  • To discuss the physiological relevance of DA receptor interactions and heteromeric assemblies.

Main Methods:

  • Analysis of existing literature on gene-targeted mice with deficiencies in DAergic transmission.
  • Comparison of behavioral data (locomotion, drug responses) from various knockout models.

Related Experiment Videos

  • Review of anatomical and neurochemical studies of the striatum in mutant mice.

    • Main Results:

    • Characterization of mice deficient in dopamine, the dopamine transporter, and all five dopamine receptor subtypes.
    • Detailed comparison of locomotor activity and responses to psychostimulants across different knockout models.
    • Insights into the morphological and neurochemical differentiation of the striatum in DAergic mutant mice.

    Conclusions:

    • Dopamine receptor knockout mice are valuable tools for understanding DAergic neurotransmission.
    • These models illuminate the roles of specific DA receptors in behavior and drug responses.
    • The study highlights the significance of receptor-receptor interactions and heteromeric receptor complexes in vivo.