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Updated: Feb 6, 2026

Humanized NOG Mice for Intravaginal HIV Exposure and Treatment of HIV Infection
Published on: January 31, 2020
Immunopathogenesis of HIV infection: concepts and questions
Abstract:
HIV infection is characterized by deficits in both the number and function of CD4 T cells, deficits in the function of other cell lines, a marked increase in cellular activation, physical disruption of the immune environment and abnormal expression of cytokines. The mechanisms for these abnormalities are not fully understood; however, these abnormalities have clinical implications, and some are already the target of therapeutic intervention. HAART has altered the natural history of HIV while simultaneously raising new questions about pathogenesis.
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