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[Novel biodegradable materials for drug delivery systems (DDS)].
A Sugitachi1, M Kashiwaba, Y Shimada
1Dept. of Surgery I, Iwate Medical University.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|November 16, 2001
Summary
New fibrin gel (FC) and chitosan sheet (BC) drug carriers were developed using UV-crosslinking. Modified FCs (Gp-UV, Cs-UV) show potential for sustained drug delivery, while BC offers rapid release.
Area of Science:
- Biomaterials science
- Drug delivery systems
- Polymer chemistry
Context:
- Developing novel biomaterials for controlled drug release is crucial for advanced therapeutics.
- Ultraviolet (UV)-crosslinking offers a versatile method for fabricating hydrogels and films.
- Fibrin gels and chitosan are biocompatible polymers with potential in biomedical applications.
Purpose:
- To synthesize and characterize four new UV-crosslinked biomaterials: fibrin gels (FC-UV, Gp-FC-UV, Cs-FC-UV) and a chitosan sheet (BC-UV).
- To evaluate the in vitro degradation profiles of these materials.
- To assess the in vitro release kinetics of cis-platinum (CDDP) from the developed drug carriers.
Summary:
- Four UV-crosslinked materials were created: FC-UV, Gp-FC-UV, Cs-FC-UV, and BC-UV, and loaded with cis-platinum (CDDP).
- Fibrin-based gels (FCs) degraded over 10-12 days, exhibiting sustained CDDP release for 10 days.
- The chitosan sheet (BC-UV) demonstrated stability for over 30 days but showed an initial burst release of CDDP.
- Modified fibrin gels (Gp-FC-UV and Cs-FC-UV) show promise as drug carriers for drug delivery systems (DDS).
Impact:
- The study introduces novel fibrin gel formulations with tunable degradation and drug release properties.
- These new materials, particularly Gp-FC-UV and Cs-FC-UV, present significant potential for future in vivo drug delivery applications.
- The findings contribute to the development of advanced drug delivery systems for cancer therapy or other treatments requiring controlled release of chemotherapeutics.