Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pinealectomy-associated decrease in ribosomal gene activity in rats.

S L Payão1, C V de Carvalho, E R da Silva

  • 1Disciplina de Genética e Biologia Molecular, Hemocentro, Faculdade de Medicina de Marília, São Paulo, Brazil. slmpayao@famema.br

Biogerontology
|November 16, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative study of the quality of breast meat of free-range chicken (Gallus gallus domesticus) and conventional chicken (Gallus gallus).

Brazilian journal of biology = Revista brasleira de biologia·2024
Same author

Optimizing the use of systemic corticosteroids in severe asthma (ROSA II project): a national Delphi consensus study.

Pulmonology·2023
Same author

Mepolizumab in severe asthma exacerbation in a respiratory ICU-a successful off-label use.

Pulmonology·2023
Same author

Eyelid Amyloid Deposition in Systemic Light Chain Amyloidosis.

Actas dermo-sifiliograficas·2022
Same author

Eyelid Amyloid Deposition in Systemic Light Chain Amyloidosis.

Actas dermo-sifiliograficas·2022
Same author

Expression of spindle assembly checkpoint proteins BubR1 and Mad2 expression as potential biomarkers of malignant transformation of oral leukoplakia: an observational cohort study.

Medicina oral, patologia oral y cirugia bucal·2021
Same journal

Emodin alleviates radiation-induced pulmonary fibrosis by targeting cellular senescence via the mtDNA-cGAS-STING axis.

Biogerontology·2026
Same journal

Natural modulators of enhancer of zeste homolog 2 (EZH2): potential epigenetic regulators of aging-associated pathways.

Biogerontology·2026
Same journal

MSC-derived extracellular vesicles accelerate wound healing in senescent fibroblast cultures.

Biogerontology·2026
Same journal

A multi-ingredient food supplement slows age-dependent decline of mobility and influences gene expression in C. elegans.

Biogerontology·2026
Same journal

Correction: Hormetic efficacy of rutin to promote longevity in Drosophila melanogaster.

Biogerontology·2026
Same journal

Identifying potential drug targets for physical and cognitive frailty: an integrative analysis of CHARLS cohort, mendelian randomization, and gene colocalization.

Biogerontology·2026
See all related articles

Aging decreases ribosomal gene activity, similar to melatonin reduction. Pineal gland removal in rats reduced nucleolar organizing region (NOR) activity, suggesting a potential animal model for aging research.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Neuroendocrinology

Background:

  • Aging is characterized by decreased ribosomal gene activity, observed in conditions like Alzheimer's disease and Down's syndrome.
  • Aging is also linked to diminished melatonin synthesis, a hormone primarily produced by the pineal gland.

Purpose of the Study:

  • To investigate the impact of pinealectomy on ribosomal gene activity, specifically nucleolar organizing region (NOR) activity, in Wistar rats.
  • To explore the potential of pinealectomy in rats as an animal model for studying the aging process.

Main Methods:

  • Cytogenetic analysis using silver-stained NOR staining was performed on 24 male Wistar rats.
  • Rats were divided into groups undergoing pinealectomy or sham surgery, with assessments at 20 days and 8 months post-surgery.

Related Experiment Videos

Main Results:

  • The absence of the pineal gland (pinealectomy) resulted in a significant decrease in NOR activity in Wistar rats.
  • This reduction in NOR activity was observed at both 20-day and 8-month post-surgery time points.

Conclusions:

  • Pinealectomy in rats leads to reduced nucleolar organizing region (NOR) activity.
  • Further research is warranted to validate pinealectomized rats as a suitable animal model for aging studies.