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p53 codon 72 polymorphism and rheumatoid arthritis.

Y H Lee¹, Y R Kim, J D Ji

¹Department of Internal Medicine, College of Medicine, Korea University, Seoul.

The Journal of Rheumatology

|November 16, 2001

Summary

The p53 codon 72 polymorphism is not associated with rheumatoid arthritis (RA) susceptibility or clinical features. Further research is needed to understand the p53 polymorphism

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Area of Science:

Genetics
Immunology
Rheumatology

Background:

Rheumatoid arthritis (RA) is a chronic autoimmune disease.
The p53 protein plays a role in cellular processes relevant to autoimmune diseases.
The p53 codon 72 polymorphism is a common genetic variation.

Purpose of the Study:

To investigate the association between the p53 codon 72 polymorphism and rheumatoid arthritis (RA) susceptibility.
To explore the relationship between the p53 codon 72 polymorphism and clinical/serological features of RA.

Main Methods:

Genotyping of the p53 codon 72 polymorphism using polymerase chain reaction-restriction fragment length polymorphism.
Analysis of 114 RA patients and 114 healthy controls.
Correlation of genotypes with clinical and serological manifestations in RA patients.

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Main Results:

No significant difference in genotype or allele frequencies of the p53 codon 72 polymorphism between RA patients and healthy controls.
No significant association found between p53 codon 72 genotypes and various clinical/serological features of RA, including age at onset, disease activity, and extraarticular manifestations.
The study was limited by small sample sizes for certain clinical features, precluding firm conclusions on their association with the polymorphism.

Conclusions:

The p53 codon 72 polymorphism is not associated with susceptibility to rheumatoid arthritis.
The role of p53 polymorphism in RA pathogenesis requires further investigation with larger cohorts and detailed clinical data.