Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular changes in psoriatic knee joint synovitis.

U Fiocco1, L Cozzi, F Chieco-Bianchi

  • 1Department of Medical and Surgical Sciences, University of Padova, Italy. ufiocco@ux1.unipd.it

The Journal of Rheumatology
|November 16, 2001
PubMed
Summary

Vascular markings in knee synovitis differ between psoriatic arthritis (PsA) and rheumatoid arthritis (RA). Computer analysis reveals unique vascular patterns in PsA, suggesting distinct disease pathways and potential for new outcome measures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Light Pseudoscalar Bosons, Pair-Produced in Higgs Boson Decays in the Four-Electron Final State in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

First Evidence for Mixing-Induced CP Violation in B_{s}^{0}→J/ψϕ(1020) Decays in pp Collisions at sqrt[s]=13  TeV.

Physical review letters·2026
Same author

Observation of Suppressed Charged-Particle Production in Ultrarelativistic Oxygen-Oxygen Collisions.

Physical review letters·2026
Same author

Measurement of D^{0} Meson Photoproduction in Ultraperipheral Heavy Ion Collisions.

Physical review letters·2026
Same author

[An unusual mass in the breast].

Radiologie (Heidelberg, Germany)·2026
Same author

Observation of tWZ Production at the CMS Experiment.

Physical review letters·2026

Area of Science:

  • Rheumatology
  • Medical Imaging
  • Pathology

Background:

  • Knee joint synovitis (KJS) is a hallmark of psoriatic arthritis (PsA) and rheumatoid arthritis (RA).
  • Understanding the macroscopic differences in synovial vascularization may elucidate distinct pathogenetic mechanisms.
  • Standard arthroscopy coupled with computerized image analysis offers a novel approach to quantify these vascular features.

Purpose of the Study:

  • To evaluate the diagnostic utility of arthroscopy with computerized image analysis for assessing knee joint synovitis (KJS).
  • To compare vascular marking (VM) features and scores in PsA and RA patients.
  • To explore the relationship between VM scores and disease activity indices.

Main Methods:

  • Arthroscopy was performed on 39 knees (20 PsA, 19 RA), with videorecordings analyzed by computer image analysis software.

Related Experiment Videos

  • Vascular markings were scored in specific synovial areas: capsular (CVM), villous (VVM), and pannus (PVM).
  • Systemic (ESR) and local KJS disease activity indices were correlated with VM scores.

    • Main Results:

    • Distinct VM features were observed in PsA and RA KJS.
    • VVM and CVM scores were significantly higher in PsA than RA and correlated with each other in PsA.
    • A unique VVM capillary feature was found in 65% of PsA knees, associated with earlier disease duration.

    Conclusions:

    • Macroscopic VM differences suggest distinct pathogenetic pathways in PsA and RA KJS.
    • The morphology and intensity of villous vascularization in PsA KJS may serve as reliable outcome measures.
    • Computer-assisted arthroscopic analysis of VM holds potential for differentiating and monitoring PsA and RA.