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Related Experiment Videos

Circulating fetal RNA in maternal plasma.

L L Poon1, T N Leung, T K Lau

  • 1Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR.

Annals of the New York Academy of Sciences
|November 16, 2001
PubMed
Summary

Cell-free fetal RNA detected in maternal plasma offers a new noninvasive method for prenatal diagnosis. This finding highlights RNA

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Effects of Maternal and Fetal Characteristics on Cell-Free Fetal DNA Fraction in Maternal Plasma.

Reproductive sciences (Thousand Oaks, Calif.)·2015

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • Cell-free nucleic acids (cfNAs) in plasma are crucial for noninvasive clinical diagnosis.
  • Recent advancements focus on utilizing cfNAs for diagnostic purposes.

Purpose of the Study:

  • To investigate the presence of cell-free fetal RNA (cffRNA) in maternal plasma.
  • To evaluate the potential of cffRNA as a biomarker for noninvasive prenatal diagnosis.

Main Methods:

  • Analysis of maternal plasma samples.
  • Detection and quantification of fetal RNA fragments.

Main Results:

  • Cell-free fetal RNA was successfully identified in maternal plasma.
  • The presence of cffRNA suggests its potential as a diagnostic marker.

Conclusions:

  • Maternal plasma contains cell-free fetal RNA.
  • Plasma fetal RNA can serve as a promising marker for noninvasive prenatal diagnosis.

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