Related Experiment Video
Updated: Aug 11, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
The phagocytosis of apoptotic cells
1National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA.
Abstract:
Apoptosis is a genetically controlled event taking care of cell turnover in healthy adult tissues and of focal elimination of cells during embryonic development. The initial phase of the program leads to corpse generation and is followed by the equally crucial removal by phagocytes. In fact, engulfment is not mere clearing of cell remnants, but rather elicits phagocyte responses able to modulate inflammation and immune reactions. The combined investigation of nematode and mammalian models has allowed, in recent years, a fast progression in the field; however, effort is still required to dissect thoroughly the molecular rules orchestrating engulfment.
Related Concept Videos
Phagocytosis
Phagocytosis
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Apoptosis
Phagocytosis of Apoptotic Cells
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Autophagic Cell Death
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Cellular Injury V: Apoptosis and Autophagy

