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Live stripping of clathrin-coated vesicles
1Università Vita-Salute San Raffaele, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milano, Italy.
Developmental Cell
|November 16, 2001
Abstract:
Vesicle budding requires recruitment of a coat, which must then be removed to allow fusion with the target compartment. In vitro assays have implicated Hsc70 and auxilin family members as key players in clathrin-coated vesicle uncoating. New in vivo studies now show that this is indeed the case and reveal additional functions of the Hsc70/auxilin complex.