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Updated: Jul 22, 2026
10:49
Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Pathogenesis of rotavirus diarrhea
1Department of Physiology, Box 432, S-405 30 Göteborg University, Göteborg, Sweden. ove.lundgren@fysiologi.gu.se
Microbes and Infection
|November 16, 2001
Summary
Rotavirus causes infantile gastroenteritis by disrupting intestinal epithelial transport. This review explores the mechanisms behind viral-induced intestinal fluid secretion.
Area of Science:
- Gastroenterology
- Virology
- Molecular Biology
Background:
- Rotavirus is a leading cause of severe diarrhea in infants globally.
- Understanding its impact on intestinal function is crucial for developing effective treatments.
Purpose of the Study:
- To review the effects of Rotavirus on intestinal epithelial transport.
- To elucidate the pathophysiological mechanisms of Rotavirus-induced fluid secretion.
Main Methods:
- Literature review of studies on Rotavirus and intestinal physiology.
- Analysis of proposed molecular and cellular mechanisms.
Main Results:
- Rotavirus infection alters ion and nutrient transport across the intestinal epithelium.
- Viral proteins disrupt tight junctions and cellular signaling pathways.
Conclusions:
- Rotavirus pathogenesis involves complex interactions affecting intestinal barrier function and fluid homeostasis.
- Further research into these mechanisms can guide therapeutic strategies against rotavirus gastroenteritis.
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