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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
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Published on: January 28, 2019

Pathogenesis of rotavirus diarrhea

O Lundgren1, L Svensson

  • 1Department of Physiology, Box 432, S-405 30 Göteborg University, Göteborg, Sweden. ove.lundgren@fysiologi.gu.se

Microbes and Infection
|November 16, 2001
PubMed

Insights

Rotavirus causes infantile gastroenteritis by disrupting intestinal epithelial transport. This review explores the mechanisms behind viral-induced intestinal fluid secretion.

Area of Science:

  • Gastroenterology
  • Virology
  • Molecular Biology

Background:

  • Rotavirus is a leading cause of severe diarrhea in infants globally.
  • Understanding its impact on intestinal function is crucial for developing effective treatments.

Purpose of the Study:

  • To review the effects of Rotavirus on intestinal epithelial transport.
  • To elucidate the pathophysiological mechanisms of Rotavirus-induced fluid secretion.

Main Methods:

  • Literature review of studies on Rotavirus and intestinal physiology.
  • Analysis of proposed molecular and cellular mechanisms.

Main Results:

  • Rotavirus infection alters ion and nutrient transport across the intestinal epithelium.
  • Viral proteins disrupt tight junctions and cellular signaling pathways.

Conclusions:

  • Rotavirus pathogenesis involves complex interactions affecting intestinal barrier function and fluid homeostasis.
  • Further research into these mechanisms can guide therapeutic strategies against rotavirus gastroenteritis.

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