Hyperbaric oxygen as an adjunct in zygomycosis: randomized controlled trial in a murine model
D M Barratt1, K Van Meter, P Asmar
1Section of Emergency Medicine and Hyperbaric Medicine, Department of Medicine, Louisiana State University, New Orleans, Louisiana 70112, USA. dbarratt@bellsouth.net
Antimicrobial Agents and Chemotherapy
|November 16, 2001
Abstract:
Zygomycosis was induced by injecting CD-1 mice with 5 mg of intraperitoneal deferoxamine and then 10(6) CFU of intravenous and intrasinus Rhizopus arrhizus. The addition of hyperbaric oxygen (2.0 atm absolute twice daily) to amphotericin B did not improve survival over that achieved with amphotericin B and placebo air treatments.
