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Genetically determined differences in the effects of morphine on mice.

E Eidelberg, R Erspamer, C J Kreinick

    European Journal of Pharmacology
    |June 1, 1975
    PubMed
    Summary
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    Morphine

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Genetics

    Background:

    • Morphine is a widely used opioid analgesic.
    • Understanding the genetic basis of morphine's behavioral effects is crucial for developing safer analgesics.

    Purpose of the Study:

    • To investigate interstrain differences in morphine's behavioral effects in mice.
    • To explore the potential genetic underpinnings of these varied responses.

    Main Methods:

    • Comparison of four mouse strains on behavioral measures including locomotor activity, analgesia, tolerance, dependence, and drug-seeking.
    • Assessment of in vivo opiate brain uptake and in vitro naloxone receptor binding.

    Main Results:

    • Analgesia and drug-seeking showed minimal interstrain variation.

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  • Locomotor activity, tolerance, and dependence exhibited distinct rank orderings across strains.
  • No significant interstrain differences were observed in brain opiate uptake or receptor binding.

    • Conclusions:

    • Different morphine effects may be controlled by independent genetic mechanisms.
    • Genetic factors significantly influence morphine's impact on locomotor activity, tolerance, and dependence.
    • Opioid brain uptake and receptor binding appear to be conserved across these mouse strains.