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Updated: Sep 16, 2026
Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
Published on: September 16, 2012
[Phenotype of peripheral blood lymphocytes in patients with lung cancer]
E K Oleĭnik1, V M Oleĭnik, I E Bakhlaev
1Institute of Biology of the Karelian Research Center, Russian Academy of Sciences, Republican Oncological Dispensary, Petrozavodsk.
Abstract:
The expression of surface markers of blood lymphocytes was studied in 32 lung cancer patients. Tumor process involved enhanced expression of the activation markers CD25, CD71 and HLA-DR as well as differentiation antigens CD4, CD8, CD22 and CD16. The expression of the markers was higher than in control, irrespective of stage, localization and histological pattern of tumor. It is suggested that increased expression of surface markers should be accounted for by tumor-induced suppression of the immune system in lung cancer.
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