[Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma]
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Updated: Oct 3, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
V Kh Khavinson1, V V Iuzhakov, I M Kvetnoĭ
1Institute of Bioregulation and Gerontology, North-Western Branch of Russian Academy of Medical Sciences, St. Petersburg.
Abstract:
The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg). The effect lasted for two weeks after injection course. Decrease in proliferative activity was not associated with the drug's immediate cytostatic action on tumor cells. The specific mechanism of the drug's action via blood flow was shown by morphological signs of hemorrhagic necrosis of tumor and increased apoptosis of tumor cells.
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