Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decreasing hair cell counts in aging humans.

S D Rauch1, L Velazquez-Villaseñor, P S Dimitri

  • 1Department of Otology and Laryngology, Harvard Medical School at Massachusetts Eye & Ear Infirmary, Boston 02114, USA. sdr@epl.meei.harvard.edu

Annals of the New York Academy of Sciences
|November 17, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mixed-dictionary models and variational inference in task fMRI for shorter scans and better image quality.

Medical image analysis·2022
Same author

R-fMRI reconstruction from k-t undersampled data using a subject-invariant dictionary model and VB-EM with nested minorization.

Medical image analysis·2020
Same author

Evaluation of weather-based rice yield models in India.

International journal of biometeorology·2012
Same author

Segmentation of left ventricle in short-axis echocardiographic sequences by weighted radial edge filtering and adaptive recovery of dropout regions.

Computer methods in biomechanics and biomedical engineering·2011
Same author

Application of crisp and fuzzy clustering algorithms for identification of hidden patterns from plethysmographic observations on the radial pulse.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010
Same author

Head rotation evoked tinnitus due to superior semicircular canal dehiscence.

The Journal of laryngology and otology·2009

Age-related balance decline is linked to vestibular system changes. This study quantifies age-related hair cell loss in the inner ear, revealing significant degeneration from birth to 100 years.

Area of Science:

  • Otolaryngology
  • Neuroscience
  • Gerontology

Background:

  • Balance problems and dizziness are common in the elderly.
  • Age-related decline affects the peripheral vestibular system, central nervous system, vision, and musculoskeletal system.
  • Vestibular function testing indicates age-related changes in both peripheral and central vestibular sites.

Purpose of the Study:

  • To quantify age-related changes in vestibular hair cells using a novel microscopy technique.
  • To establish a normative database of vestibular hair cell counts across the human lifespan.
  • To provide a basis for correlating vestibular otopathology with clinical findings and disorders.

Main Methods:

  • Utilized Nomarski differential interference contrast microscopy for quantitative assessment of vestibular otopathology.

Related Experiment Videos

  • Analyzed 67 human temporal bones from individuals aged birth to 100 years.
  • Developed a normative database of total, type I, and type II hair cell counts as a function of age.

    • Main Results:

    • Demonstrated a significant, continuous, linear decrease in all hair cell counts (total, type I, type II) from birth to age 100.
    • Type I hair cells in semicircular canal cristae showed faster degeneration than those in maculae.
    • Type II hair cells exhibited a consistent decline rate across all five sensory epithelia.

    Conclusions:

    • Established normative data for age-related vestibular hair cell loss.
    • These findings provide a foundation for comparing pathological temporal bone findings with clinical vestibular assessments.
    • The data facilitate correlations between vestibular function test results and underlying vestibular otopathology.