Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Subviral Agents01:29

Subviral Agents

583
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
583
Resistivity01:22

Resistivity

4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

6.0K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Equivalent Resistance01:16

Equivalent Resistance

996
In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
996
Resistance and Conductance01:25

Resistance and Conductance

523
A conductor's DC resistance at a given temperature is influenced by its resistivity, length, and cross-sectional area. Resistivity is an inherent property of the conductor material, with annealed copper serving as the international standard for measurement. For instance, the resistivity of hard-drawn aluminum at 20 degrees Celsius is 61% of the standard conductivity of annealed copper.
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
523
Rolling Resistance01:21

Rolling Resistance

675
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
675

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical evaluation of the cardiac toxicity of HMR-1826, a novel prodrug of doxorubicin.

British journal of cancer·1999
Same author

A national survey of human Mycobacterium bovis infection in France. Network of Microbiology Laboratories in France.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·1999
Same author

Thoracic outlet syndrome: influence of personal history and surgical technique on long-term results.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·1999
Same author

Outcome of multi-drug-resistant tuberculosis in France: a nationwide case-control study.

American journal of respiratory and critical care medicine·1999
Same author

Beneficial effects of leukocyte-depleted blood and low-potassium dextran solutions on microvascular permeability in preserved porcine lung.

American journal of respiratory and critical care medicine·1999
Same author

Incidence, risk factors and management of bronchopleural fistulae after pneumonectomy.

Scandinavian cardiovascular journal : SCJ·1999

Related Experiment Video

Updated: Feb 10, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

14.0K

Resistance to cytotoxic agents.

J Robert1

  • 1Institut Bergonié et Université Victor Segalen Bordeaux 2, France. robert@bergonie.org

Current Opinion in Pharmacology
|November 17, 2001
PubMed
Summary

Conflicting results on apoptosis impairment and drug resistance challenge the dogma that apoptosis universally determines drug activity. Cell-type specific pathways and new genetic tools are crucial for understanding anticancer drug resistance.

Area of Science:

  • Molecular Biology
  • Genetics
  • Pharmacology

Background:

  • Conflicting data exists regarding the role of impaired apoptosis in cytotoxic drug resistance.
  • This challenges the established view of apoptosis as a universal factor in drug efficacy.

Purpose of the Study:

  • To investigate the cell-type specificity of apoptotic pathways in relation to drug resistance.
  • To explore novel genetic tools for identifying genes and pathways involved in anticancer drug resistance.

Main Methods:

  • Utilizing differential or subtractive gene expression analyses, including cDNA microarrays.
  • Employing genetic suppressor elements for functional identification of resistance genes.

Main Results:

  • New genetic tools facilitate the identification of multiple genes and complex pathways implicated in drug resistance.

More Related Videos

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K
Real-time Cytotoxicity Assays in Human Whole Blood
08:27

Real-time Cytotoxicity Assays in Human Whole Blood

Published on: November 7, 2014

12.7K

Related Experiment Videos

Last Updated: Feb 10, 2026

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel
06:44

Generation of Prostate Cancer Cell Models of Resistance to the Anti-mitotic Agent Docetaxel

Published on: September 8, 2017

14.0K
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

11.2K
Real-time Cytotoxicity Assays in Human Whole Blood
08:27

Real-time Cytotoxicity Assays in Human Whole Blood

Published on: November 7, 2014

12.7K
  • Cell-type specific apoptotic pathways are likely responsible for the divergent results observed in previous studies.

    • Conclusions:

    • The role of apoptosis in drug resistance is complex and highly cell-type specific.
    • Advanced genetic techniques are essential for a comprehensive understanding of anticancer drug resistance mechanisms.