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Related Experiment Videos

Natural products in anticancer therapy.

A B da Rocha1, R M Lopes, G Schwartsmann

  • 1Comprehensive Cancer Center, The Lutheran University of Brazil, Canoas, RS.

Current Opinion in Pharmacology
|November 17, 2001
PubMed
Summary

Natural products from plants, microbes, and marine life are vital sources for discovering anticancer drugs. Many plant-derived, microbial, and marine-based compounds are currently used in cancer treatment or clinical trials.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Oncology

Background:

  • Natural products from diverse organisms have historically yielded crucial pharmaceutical agents.
  • Plants, microorganisms, and marine organisms represent rich reservoirs for drug discovery.
  • Several established anticancer drugs are derived from natural sources.

Purpose of the Study:

  • To highlight the significance of natural products in the discovery of anticancer agents.
  • To provide examples of anticancer drugs derived from plants, microbes, and marine organisms.
  • To review marine-derived compounds currently in clinical development for cancer treatment.

Main Methods:

  • Literature review of natural product-derived anticancer agents.
  • Categorization of agents based on their natural source (plant, microbial, marine).
  • Identification of marine-derived compounds in clinical trials.

Main Results:

  • Plant-derived anticancer drugs include vincristine, irinotecan, etoposide, and paclitaxel.
  • Microbial sources have yielded anticancer agents such as dactinomycin, bleomycin, and doxorubicin.
  • Marine sources have provided anticancer agents like cytarabine, with bryostatin-1, aplidine, dolastatin 10, and ET-743 in clinical trials.

Conclusions:

  • Natural products remain a fundamental resource for anticancer drug discovery.
  • Marine organisms are an increasingly important source of novel anticancer drug candidates.
  • Continued exploration of natural products holds promise for future cancer therapies.

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