Radiolabeled peptides in diagnosis and therapy

Area of Science:

• Nuclear Medicine
• Radiopharmaceutical Chemistry
• Oncology

Background:

• Peptides are increasingly used in nuclear medicine for diagnostic and therapeutic applications.
• Their favorable properties include ease of synthesis, rapid clearance, minimal immunogenicity, and high affinity for cancer cell receptors.

Purpose of the Study:

• To review the chemistry, preparation, and applications of radiolabeled peptides.
• To highlight their use in imaging and therapy, with a focus on oncology.

Main Methods:

• Discussion of peptide chemistry and synthesis.
• Overview of radiolabeling techniques using chelating moieties.
• Review of applications in imaging (thrombosis, infection, inflammation, tumors) and therapy.

Main Results:

• Radiolabeled peptides demonstrate significant potential in various clinical and experimental applications.
• Several radiolabeled peptides are approved or in clinical trials, with promising preclinical agents also identified.

Conclusions:

• Radiolabeled peptides represent a rapidly growing field with broad applications in medical imaging and cancer therapy.
• Ongoing research and development continue to expand their clinical utility.